Herein, we reported the fabrication of copper ion-doped ZIF-8 loaded with gold nanozymes and doxorubicin hydrochloride (DOX) for the chemotherapy and CDT synergistic treatment of tumors with the assistance of tumor microenvironment (TME)-activated fluorescence imaging.
In summary, extrusion is a highly efficient method to generate a large quantity of therapeutic NVs that can potentially replace extracellular vesicles in regenerative medicine applications.Ĭhemodynamic therapy (CDT) is widely explored for tumor-specific therapy by converting endogenous H2O2 to lethal In addition, NV therapy promoted angiogenesis and proliferation of cardiomyocytes in the post-injury heart. Such therapeutic benefits are similar to those injected with natural EVs from the same MSC parental cells. Intramyocardial delivery of NVs in the injured heart after ischemia-reperfusion led to a reduction in scar sizes and preservation of cardiac functions. In vitro, cell-based assays demonstrated the myocardial protective effects and therapeutic potential of NVs. The yield of NVs is 20-fold more than that of EVs. Those extruded nanovesicles (NVs) are miniature versions of MSCs in terms of surface marker expression. We sought to develop a scale-up friendly method to generate a large number of therapeutic nanovesicles from MSCs by extrusion. However, the large-scale production of EVs remains a challenge. The therapeutic potential of MSC-EVs has been established in various cardiac injury preclinical models. One of the important paracrine components of MSC secretomes is the extracellular vesicle (EV). Mesenchymal stem cells (MSCs) repair injured tissues mainly through their paracrine actions.
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